Kansas City (2-2) laid a thorough 41-14 beatdown on the visiting Patriots (2-2) on Monday night.
Alex Smith threw three touchdown passes, two of them to Jamaal Charles, who added another on the ground.
Charles & Knile Davis combined for 199 rushing yards, while Travis Kelce had eight catches for 93 yards and one score.
The KC defense entered the game with no takeaways, but turned Tom Brady over three times, including a 39-yard pick-six by Husain Abdullah in the fourth quarter.
The Chiefs have scored 75 points in their past two games, after having totaled just 27 in their first two; they head to San Francisco next week and then have their bye.
New England, which managed just 13 first downs, will host the undefeated Bengals on Sunday.