The Chargers (3-1) pulled a half-game ahead of the idle Broncos (2-1) with a 33-14 thrashing of the visiting Jaguars (0-4).
Philip Rivers threw for 377 yards and three touchdowns, including two to former friend Eddie Royal.
Blake Bortles kept Jacksonville in the game in the opening half of his first NFL start, leading them on two second-quarter touchdown drives.
Those staked the Jags to a 14-10 lead, but San Diego piled on 24 unanswered points after that.
The Chargers could easily be 6-1 entering their Week 8 Thursday night game in Denver.
San Diego entertains the Jets next week, visits Oakland, and then hosts Kansas City in Week 7.
The Raiders (0-4) continue to reel, losing 38-14 to the Dolphins (2-2) in London.
Starting quarterback Derek Carr was forced out with ankle and knee injuries, although X-rays were negative.
Following Carr's departure, a botched shotgun snap by Stefen Wisniewski resulted in a Miami touchdown for the game's final score.
Oakland has now lost ten straight games heading into their bye, and even Bill Williamson is now calling for Dennis Allen's ouster.
The Raiders are just 8-28 under Allen, who reportedly could be replaced by OC Greg Olson or assistant head coach Tony Sparano.
Kansas City (1-2) hosts New England (2-1) on Monday night.