The most obvious effects of Von Miller's torn ACL are that it ends his 2013 season, and is a significant blow to Denver's Super Bowl chances.
While the injury has the potential to affect Miller's career for the long term, that would seem a lesser concern at this point, given how well players tend to recover from ACL injuries.
But as the Broncos' coaches and players continue to focus on locking down HFA and their playoff run, the front office will face a big decision on Miller as soon as their regular season ends.
Obviously, this is a huge blow to Denver's SB chances, but if anything can cover for such a loss, it's the presence of Peyton Manning.
While the AFC playoff field is mostly set, with only one spot available, and seeding yet to be determined, the NFC is almost completely up for grabs.
Only two NFC squads (Seattle and Carolina) have clinched playoff berths, but no division titles have been claimed.
Philly (9-6) annihilated Chicago (8-7) to the tune of a 54-11 embarrassment, while Dallas (8-7) pulled off a 24-23 victory over Washington (3-12), thanks to a late touchdown from the unclutch (especially in December!) Tony Romo.
After 16 weeks, five of the AFC's playoff spots have been claimed, and four teams have a chance at the last Wild Card berth.
The Broncos, Colts, Pats, and Bengals own the four division crowns, while the Chiefs have the first Wild Card. Only KC has its seed - the fifth - while only the Broncos have clinched a bye.
Denver (12-3) clinched the AFCW and a first-round bye on Sunday, and can nail down HFA with a win or tie at Oakland, or a New England (11-4) loss or tie against the visiting Bills.
If true, this would obviously be stellar news for the Broncos. Holding Miller out of the finale would provide him three weeks between games, with the Broncos having already clinched a first-round bye.
Peyton Manning is the NFL's new single-season touchdown pass king.
With his fourth scoring throw of the Broncos' Week 16 game at Houston, and his 51st of the year - this a picturesque toss to Julius Thomas - Manning broke the record previously set by Tom Brady in 2007.
On the Texans' sixth play from scrimmage, Von Miller went down awkwardly with an apparent knee injury, and the Broncos have already ruled him out for the rest of the game.
According to Mike Klis, the team fears it may be a torn ACL; Miller will undergo an MRI on Monday.
Commence hand-wringing, Broncos fans.
According to Jeff Legwold and Chris Mortensen, the Broncos are expected to rule Wes Welker out for Sunday's game at Houston, and then also rest him for the regular season finale at Oakland.
Welker had suffered two concussions in a span of 22 days (against Kansas City and Tennessee), so this would appear to be a sensible decision - that is, if he should return at all this season.
In order to create room on the roster for the newly signed DE Jeremy Mincey, Denver waived center J.D. Walton on Tuesday.
Walton started 36 straight games straight out of college, but his career was derailed by a gruesome leg injury suffered in September 2012.
Jacksonville had cut Mincey last week over repeated issues of tardiness and violation of team rules.
The 6-4, 265-pounder was drafted by the Patriots in 2006, and played under Jack Del Rio for 4.5 seasons with the Jaguars.