The Broncos placed linebacker Nate Irving on IR on Thursday; he sprained an MCL at New England in Week 9.
Taking Irving's place on the roster will be linebacker Todd Davis, whom Denver claimed off waivers from New Orleans.
Jeff Fisher will start Shaun Hill at quarterback over Austin Davis against Denver on Sunday.
Just two days earlier, Fisher had offered a lukewarm confirmation that Davis would remain the starter after a disastrous game against Arizona.
According to the DP, Ronnie Hillman will miss at least two weeks with a foot sprain he suffered at Oakland on Sunday.
Denver travels to face the Rams in St. Louis this Sunday, before hosting Miami in Week 12.
The week after that, they'll face the Chiefs on SNF at Arrowhead. The current timeline would have Hillman back for that showdown.
According to the DP, Nate Irving's MRI on Monday showed a sprained MCL that may not end his season.
However, Irving's knee reportedly has significant swelling, and more tests are required.
Per Mike Klis, Denver plans to start either Lamin Barrow or Steven Johnson in his place.
Nate Irving will undergo an MRI on Monday to determine the severity of the injury to his right knee.
According to Mike Klis, the Broncos fear Irving's injury is serious.
The Broncos expectedly ruled out Omar Bolden (concussion) and Montee Ball (groin) for Thursday's game against San Diego.
Steven Johnson (ankle) is questionable, while five others are listed as probable.
Ball is reportedly progressing, and may practice on a limited basis next week, prior to Denver's game at New England.
Denver's Wednesday injury report is a carbon copy of Tuesday's; Brandon McManus (groin), Steven Johnson (ankle), Omar Bolden (concussion), and Montee Ball (groin) were again held out.
Ball is improving and did some conditioning work, but he'll miss Thursday's game against San Diego; Johnson and Bolden are also expected to sit.
As wins over Seattle and Buffalo became a significant streak with victories over the lesser Jags and Jets, San Diego had done wonders to overcome injuries.
But then they barely squeaked past Oakland last week, and on Sunday, they lost at home to Kansas City, allowing the Chiefs 154 rushing yards and 39 minutes of TOP.
San Francisco will be without key starters Patrick Willis (toe) and Mike Iupati (concussion) on Sunday.
The Broncos have placed linebacker Danny Trevathan on short-term IR; he'll be eligible to return for their Week 15 game at San Diego.
Trevathan fractured a bone above his left knee early in Denver's 31-17 win over the Jets.
A fracture below the same knee during training camp had caused him to miss the Broncos' first three games.