Peyton Manning threw four touchdown passes, including three to Demaryius Thomas.
Despite that gaudiness, C.J. Anderson and Emmanuel Sanders were Denver's biggest stars of the day, amassing a whopping 323 yards from scrimmage.
Oakland (1-10) pulled off the shocker on Thursday night, knocking off the rival first-place Chiefs (7-4) in a 24-20 victory.
The win broke a 16-game losing streak for the Raiders; their last win came November 17, 2013, and that was against a Texans team amidst their own 14-game losing streak.
Derek Carr led Oakland on a late 80-yard scoring drive, throwing a game-winning nine-yard touchdown pass to James Jones inside the two-minute warning.
It was hard to get excited for Sunday's game; there was little upside to it, and only a blowout win would be satisfactory from Denver's standpoint.
What followed was pretty much the worst case scenario, short of an injury to Peyton Manning.
Denver (7-2) and Peyton Manning overcame an ugly opening 20 minutes to unleash five straight touchdown passes in a 41-17 drubbing at Oakland (0-9).
A pair of interceptions by Manning helped stake the Raiders to an early 10-6 lead, but the first-place Broncos poured it on from there.
Manning finished with 340 yards, five scores, and two picks in three quarters of play.
Emmanuel Sanders and Julius Thomas each caught a pair of touchdowns, while C.J. Anderson added 163 yards from scrimmage and a highlight reel 51-yard score.
Peyton Manning threw a pair of touchdowns passes, but each of his two interceptions led to a short touchdown drive for New England.
Tom Brady threw four touchdown passes, while his one pick occurred with the Pats already ahead by 20 points.
Kansas City (5-3) leapfrogged over San Diego (5-4) into second place in the AFCW by winning their third straight game.
The Chiefs easily handled the visiting Jets 24-10, handing the LOL worthy team their eighth consecutive loss.
Emmanuel Sanders caught three touchdown passes from Peyton Manning, and Juwan Thompson added two short rushing scores.
Ronnie Hillman had another big game, with 138 yards from scrimmage for his third straight 100-yard game in as many starts.
Peyton Manning threw for 318 yards and four touchdown passes, with his third breaking Brett Favre's all-time mark.
Two of them went to Demaryius Thomas, whose eight catches went for 171 yards.
Kansas City (3-3) handed San Diego (5-2) a 23-20 home loss, giving Denver a chance to pull ahead of the Chargers with a win over San Francisco.
After the Chargers tied the game at 20 just inside the two-minute warning, Alex Smith drove the Chiefs to a game-winning field goal by Cairo Santos.
Dallas (5-1) outdistanced Seattle (3-2) handily in yards (401-206), first downs (23-9), and TOP (37:39-22:21) on their way to a 30-23 road win over the defending champs.
DeMarco Murray topped 100 yards for the sixth straight week, while the reborn Rolando McClain ensured the Cowboys' upset with a late interception of Russell Wilson.