Emmanuel Sanders caught three touchdown passes from Peyton Manning, and Juwan Thompson added two short rushing scores.
Ronnie Hillman had another big game, with 138 yards from scrimmage for his third straight 100-yard game in as many starts.
Peyton Manning threw for 318 yards and four touchdown passes, with his third breaking Brett Favre's all-time mark.
Two of them went to Demaryius Thomas, whose eight catches went for 171 yards.
Kansas City (3-3) handed San Diego (5-2) a 23-20 home loss, giving Denver a chance to pull ahead of the Chargers with a win over San Francisco.
After the Chargers tied the game at 20 just inside the two-minute warning, Alex Smith drove the Chiefs to a game-winning field goal by Cairo Santos.
Dallas (5-1) outdistanced Seattle (3-2) handily in yards (401-206), first downs (23-9), and TOP (37:39-22:21) on their way to a 30-23 road win over the defending champs.
DeMarco Murray topped 100 yards for the sixth straight week, while the reborn Rolando McClain ensured the Cowboys' upset with a late interception of Russell Wilson.
The Patriots (4-2) proved again that they're far from dead with a 37-22 win at Buffalo (3-3) on Sunday.
Tom Brady threw four touchdown passes, but running back Stevan Ridley exited with what's feared to be a torn ACL.
San Diego (5-1) remained a half-game ahead of Denver (4-1) with a 31-28 shootout win over Oakland (0-5).
Philip Rivers tossed three touchdown passes, while Branden Oliver scored once and topped 100 yards for the second straight week.
Peyton Manning threw three touchdown passes, two of them to Julius Thomas, and Ronnie Hillman hit the 100-yard mark in his first NFL start.
Demaryius Thomas added 10 catches for 124 yards and a score, Von Miller notched two sacks, and Aqib Talib iced the game with a late pick-six.
We’d love to focus on Peyton Manning’s 500th career touchdown pass, but we wouldn’t want to do so at the expense of numbers 501, 502, and 503.
Thomas broke Shannon Sharpe's mark of 214 yards, established during a 2002 overtime win at Kansas City.
Kansas City (2-2) laid a thorough 41-14 beatdown on the visiting Patriots (2-2) on Monday night.
Alex Smith threw three touchdown passes, two of them to Jamaal Charles, who added another on the ground.
The Chargers (3-1) pulled a half-game ahead of the idle Broncos (2-1) with a 33-14 thrashing of the visiting Jaguars (0-4).
Philip Rivers threw for 377 yards and three touchdowns, including two to former friend Eddie Royal.